Cortical Disarray Measurement

The challenge

Dementia – A Global Healthcare Crisis. Our breakthrough technology is helping us to rethink the way brain health is assessed.

Disease prevalence

Global estimates suggest 416 million people around the world are on the Alzheimer's disease continuum.

Drug Discovery

More than 200 experimental drugs have failed in clinical trials.

Public health crisis

Every 3 seconds someone is diagnosed with Dementia.

MRI Scans

Current imaging technologies only measure brain volume which gives limited information. 50% of dementia sufferers are undiagnosed and many others are misdiagnosed.

Our solution

Cortical Disarray Measurement (CDM®) software as a device has been granted Breakthrough Device Designation by the U.S. Food and Drug Administration (FDA). Only our proprietary technology analyses grey matter quality and uncovers insights of the kind that we do, based on changes in the brain at a cellular level. 
Our sophisticated diffusion analysis is based on a deep understanding of neuropathology, and the correlations between microscopic brain data and MRI analysis. Our histology model is built with scientific rigour and validated by post-mortem comparison at the microscopic scale.

Our science

Dr Steven Chance (CEO & Co-Founder) and Prof. Mark Jenkinson (Co-Founder) are world-leading authorities in neuropathology and neuroimaging. The Minicolumn anatomy which lies at the heart of the CDM® method, is altered in the neuropathology of Alzheimer’s disease, and other neurological and psychiatric disorders. Our method is built on decades of direct observation of brain tissue and MRI research at the University of Oxford.

Cortical Disarray Measurement (CDM®)

Our products


  • Measures you can trust
  • Get more from your MRI
  • Run targeted, more efficient clinical trials
  • Efficient use of technology across multiple conditions

Our products


  • Supporting patient care
  • Helping clinicans in their diagnosis
  • Differential patterns of brain changes
  • Accurately tracking changes
  • Proactive brain health

Clinical Information